Acetylcholinesterase Inhibitors from Angelica polymorpha Stem.
10.20307/nps.2017.23.2.97
- Author:
Yongsoo KWON
1
;
Hyun Pyo KIM
;
Myong Jo KIM
;
Wanjoo CHUN
Author Information
1. College of Pharmacy, Kangwon National University, Chuncheon 24341, Korea. yskwon@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Angelica polymorpha;
Coumarins;
Chromones;
Acetylcholinesterase inhibitory effect
- MeSH:
Acetylcholinesterase*;
Angelica*;
Cholinesterase Inhibitors*;
Chromones;
Coumarins;
Scopoletin
- From:Natural Product Sciences
2017;23(2):97-102
- CountryRepublic of Korea
- Language:English
-
Abstract:
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin (5), geijerine (6), (−)-3'-acetyl hamaudol (7), 7-demethylsuberosine (8), dehydrogeijerin (9), (−)-hamaudol (10), (+)-visamminol (11), divaricatol (12), scopoletin (13), and decursidate (14), respectively. Among them, compounds 4 - 6, 8, 9, 13, and 14 were isolated for the first time from A. polymorpha. Dehydrogeijerin (6) and geijerin (9) were isolated for the first time from genus Angelica. All isolates tested for inhibitory activity against acetylcholinesterae. Compounds 1 to 13 showed acetylcholinesterase inhibitory activity with IC₅₀ values ranging from 1.4 to 37.5 µM.
