Flavonoid Compounds from the Leaves of Kalanchoe prolifera and Their Cytotoxic Activity against P-388 Murine Leukimia Cells.
10.20307/nps.2017.23.2.139
- Author:
Lilis Siti AISYAH
1
;
Yenny Febriani YUN
;
Tati HERLINA
;
Euis JULAEHA
;
Achmad ZAINUDDIN
;
Ida NURFARIDA
;
Ace Tatang HIDAYAT
;
Unang SUPRATMAN
;
Yoshihito SHIONO
Author Information
1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Achmad Yani, University, Cimahi 40528, Indonesia.
- Publication Type:Original Article
- Keywords:
Flavonoids;
Kalanchoe prolifera;
Crassulaceae;
P-388 murine leukimia cell
- MeSH:
Crassulaceae;
Flavonoids;
In Vitro Techniques;
Kalanchoe*;
Methanol;
Plants;
Quercetin
- From:Natural Product Sciences
2017;23(2):139-145
- CountryRepublic of Korea
- Language:English
-
Abstract:
Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-β-D-glucopyranoside (3), kaempferol-3-O-β-D-glucopyranoside (4), kaempferol-3-O-α-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC₅₀ values of 4.45 ± 0.05 and 6.28 ± 0.02 µg/mL, respectively.
