Survival analysis of HIV-infected patients on antiretroviral therapy during 2006-2019 in Taizhou City
10.19428/j.cnki.sjpm.2021.20396
- VernacularTitle:2006—2019年台州市抗病毒治疗的HIV感染者生存状况分析
- Author:
Xiao-qin LI
1
;
Jia-yu HE
2
;
Shan-ling WANG
3
;
Yuan-yuan XU
3
;
Wei-wei SHEN
3
;
Ying-ying DING
2
;
Na HE
2
;
Xiao-xiao CHEN
3
Author Information
1. Xianju Prefecture Center for Disease Control and Prevention， Taizhou， Zhejiang 317300， China
2. School of Public Health， Key Laboratory of Public Health Safety of Ministry of Education， Fudan University， Shanghai 200032， China
3. Taizhou Center for Disease Control and Prevention， Taizhou， Zhejiang 318000， China
- Publication Type:Research Article
- Keywords:
HIV infected patients;
antiretroviral therapy;
survival status;
influencing factor
- From:
Shanghai Journal of Preventive Medicine
2021;33(9):779-784
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the survival status and explore factors related to death among human immunodeficiency virus （HIV） infected patients receiving antiretroviral therapy （ART） in Taizhou City during 2006‒2019. Methods:A retrospective cohort study was conducted to analyze the data on HIV-infected patients receiving ART in Taizhou during 2006‒2019. Kaplan-Meier （K-M） method was used to calculate the cumulative survival rate and cumulative treatment success rate. Cox regression model was used to determine survival status and factors associated with ART. Results:A total of 2 904 HIV-infected patients was included. The cumulative survival rate after 1， 3， 5， and 8 years of ART were 96.9%， 94.9%， 93.1% and 92.1%， respectively， and the cumulative treatment response rate were 91.3%， 85.3%， 81.8% and 73.8%， respectively. Compared with aged 18-30 years old， baseline CD4+T cell >350 count/μL， normal hemoglobin level， effective ART， no clinical symptom at baseline， and homosexual transmission， we found that aged 51-60 years old（HR=4.94，95%CI：1.66-14.69）， aged over 60 years old（HR=9.14，95%CI：3.14-26.63）， anemia at baseline（HR=2.24，95%CI：1.55-3.23）， baseline CD4+T cell <200 count/μL（HR=4.35，95%CI：2.14-8.86）， ART failure （HR=3.90，95%CI：2.73-5.58）， heterosexual transmission（HR=1.92，95%CI：1.15-3.20）， and signs of symptom at baseline（HR=1.68，95%CI：1.16-2.41） were risk factors of HIV-related death. Conclusion:The effect of ART in Taizhou City is confirmed with a high cumulative survival rate and treatment success. We should pay additional attention to senior HIV-infected patients with anemia at baseline and intensively monitor the effect of ART. Interventions such as “treat after discover” are supposed to be implemented more widely to further reduce HIV-related mortality.
