The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis
10.16438/j.0513-4870.2021-0238
- VernacularTitle:HIF-VEGF-Ang-2信号转导介导的滑膜血管新生在类风湿关节炎中的作用
- Author:
Pei-rong GAN
1
;
Chao LIU
2
;
Hong WU
1
;
Xin-tong DONG
1
;
Jiang-tao KE
1
;
Fang-yuan CHEN
1
Author Information
1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin'an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
2. School of Basic Medicine, Anhui Medical University, Hefei 230032, China
- Publication Type:Research Article
- Keywords:
rheumatoid arthritis;
angiogenesis;
hypoxia-inducible factor;
vascular endothelial growth factor;
angiopoietin-2
- From:
Acta Pharmaceutica Sinica
2021;56(5):1246-1252
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is an autoimmune disease with angiogenesis, inflammatory factor infiltration and joint destruction as the main pathological features. Angiogenesis promotes the development of RA and plays an important role in its pathogenesis. The hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin-2 (Ang-2) signal transduction is a critical pathway to induce synovial angiogenesis. Targeting HIF-VEGF-Ang-2 signal transduction to inhibit synovial angiogenesis is a promising approach for RA treatment. This article reviews the role and mechanism of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in RA, in order to provide a new target and strategy for RA treatment.
