Application of stable isotope-resolved metabolomics in glucose catabolism

VernacularTitle:稳定同位素示踪代谢组学技术在葡萄糖分解代谢研究中的应用进展
Author: Wen-ze WU ¹ ; Ting LINGHU ¹ ; Yao GAO ¹ ; Yun-hao ZHAO ¹ ; Yu-mei HAN ² ; Xue-mei QIN ¹ ; Jun-sheng TIAN ¹
Author Information

1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. School of Physical Education, Shanxi University, Taiyuan 030006, China
Publication Type:Research Article
Keywords: stable isotope-resolved metabolomics; glucose catabolism; metabolic pathway; metabolic flux
From: Acta Pharmaceutica Sinica 2021;56(5):1286-1292
CountryChina
Language:Chinese
Abstract: With the rapid development of high sensitivity detection techniques such as nuclear magnetic resonance and mass spectrometry, stable isotope-resolved metabolomics has been widely used in elucidating the regulatory mechanism of metabolic pathways and metabolic flow analysis, and some breakthroughs have been made. In this paper the application of stable isotope-resolved metabolomics in glucose catabolic regulation, metabolic flow analysis and functional interpretation of key metabolic pathways is reviewed, providing references for the wider use and application of this technology.