Full-factor design of experiment application in the development of printing ink for binder jetting 3D printed preparation
10.16438/j.0513-4870.2020-1904
- VernacularTitle:全因子实验设计在黏结剂喷射型3D打印制剂打印液开发中的应用
- Author:
Zeng-ming WANG
;
Xian-fu LI
;
Xiao-lu HAN
;
Ai-ai LIU
;
Xiao-xuan HONG
;
Cong-hui LI
;
Ai-ping ZHENG
- Publication Type:Research Article
- Keywords:
binder jetting technology;
3D printing;
levetiracetam dispersible tablet;
printing ink;
esign space;
jetting mechanism
- From:
Acta Pharmaceutica Sinica
2021;56(5):1460-1469
- CountryChina
- Language:Chinese
-
Abstract:
The development of printing ink is a challenge for binder jetting 3D printed preparations, which directly determines the quality of the printed product. This study adopted a 23 full-factor Design of Experiment (DoE) with three central points to optimize the printing ink composition of levetiracetam 3D printed dispersible tablet based on the concept of Quality by Design. Firstly, using polyvinyl pyrrolidone K30, glycerin and polysorbate 20 as independent variables based on 40% (v/v) isopropanol aqueous solution, and weight variation, hardness, friability and dispersion uniformity of the printed tablets were used as dependent variables. Then obtained the design space of the printing ink prescription by DoE model analysis, and the response optimizer was used to obtain the optimal printing ink prescription: isopropanol aqueous solution containing 0.1% (w/w) polyvinyl pyrrolidone K30 and 4.0% (w/w) glycerin. The jetting mechanism and wettability of the printing ink were analyzed, and different strengths of personalized 3D printed tablets were prepared and characterized, which verified the rationality of the printing ink formulation. This study provided a reference for the development of printing ink for binder jetting 3D printed preparations.
