Glycyrrhizic acid: a potential drug against COVID-19
- VernacularTitle:甘草酸: 一种治疗新型冠状肺炎的潜在药物
- Author:
Fu-jing GE
1
;
Chen-ming ZENG
1
;
Fang-jie YAN
2
;
Mei-jia QIAN
1
;
Wei-hua WANG
1
;
Pei-hua LUO
1
;
Qin-jie WENG
1
;
Rang-xiao ZHUANG
3
;
Jian-jun XI
3
;
Jin-song HUANG
3
;
Bo YANG
1
;
Hong ZHU
1
;
Qiao-jun HE
1
,
4
Author Information
- Publication Type:Research Article
- Keywords: SARS-CoV-2; COVID-19; glycyrrhizic acid; cytokine storm; anti-inflammatory treatment; antiviral therapy
- From: Acta Pharmaceutica Sinica 2021;56(5):1211-1216
- CountryChina
- Language:Chinese
- Abstract: Pneumonia caused by SARS-CoV-2 has seriously threatened human life and health worldwide and caused a large number of deaths. Viral infection and acute inflammation are important causes of death, so it is particularly important to combine antiviral therapy with anti-inflammatory therapy. Glycyrrhizic acid, the main component of the glycyrrhizic root extract, has a wide range of pharmacological effects as well as high efficiency and low toxicity, its preparation has been widely used in the treatment of chronic hepatitis and other diseases. Glycyrrhizic acid can regulate the expression and release of a variety of cytokines and play a significant anti-inflammatory effect. At the same time, glycyrrhizic acid also showed significant inhibition towards a variety types of viruses. Therefore, the potential application of glycyrrhizic acid as COVID-19 treatment should be explored.
