Nucleocytoplasmic transport and neurodegenerative diseases
10.16438/j.0513-4870.2020-1796
- VernacularTitle:核质转运异常与神经退行性疾病
- Author:
Zi-jian WANG
1
;
Zi-heng LI
1
;
Yi-kun CHANG
2
;
Tian ZHANG
1
;
Yuan-yuan REN
1
;
Feng-qin HE
1
Author Information
1. Key Laboratory of Natural Product Development and Anticancer Innovative Drug Research in Qinling, Xi'an University, Xi'an 710065, China
2. College of Medicine, Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Research Article
- Keywords:
nucleocytoplasmic transport;
neurodegenerative disease;
pathogenesis;
rug target
- From:
Acta Pharmaceutica Sinica
2021;56(5):1217-1228
- CountryChina
- Language:Chinese
-
Abstract:
Nucleocytoplasmic transport is the basic cellular activity of eukaryotic cells, which plays a role in cell physiological and pathological processes. A large amount of evidences indicate that impaired nucleocytoplasmic trafficking has emerged as a mechanism contributing to the pathology of neurodegenerative diseases. The regulation of nucleocytoplasmic transport is crucial to elucidate the pathogenesis and intervention in the neurodegenerative diseases. This article summarizes the evidences in disturbed nucleocytoplasmic transport of neurodegenerative diseases in the past two decades, further explores the directions and provides a theoretical basis for the pathogenesis and drug targets in neurodegenerative diseases.
