Research progress in the application of glass transition phenomenon in pharmaceutics
10.16438/j.0513-4870.2020-1755
- VernacularTitle:玻璃化转变现象在药剂学中的应用研究进展
- Author:
Qiu-fang CAO
1
;
Xiao-yong RAO
1
;
Yao ZHANG
1
;
Ai-ling ZHANG
1
;
Min LI
2
;
Zhe LI
1
;
Xiao-jian LUO
1
Author Information
1. National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
2. Yangzijiang Pharmaceutical Group Co., LTD., Taizhou 225300, China
- Publication Type:Research Article
- Keywords:
glass transition;
amorphous;
temperature;
moisture content;
pharmaceutics;
stability
- From:
Acta Pharmaceutica Sinica
2021;56(5):1301-1313
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the phenomenon of glass transition has been gradually applied to the field of pharmaceutics. And it exhibits important influences on multiple operating units of pharmaceutical preparations, and the properties and storage of pharmaceutical intermediates and products. At present, it has been widely used in the process of preparations such as drying, granulation, coating, tableting, holt-melt extrusion, cryogenic comminution, and so on. Meanwhile, it showed guiding significance for the process of preparation intermediates and their products, such as solid dispersion, microcapsule, liposome, particle, tablet, and other preparation intermediates and their products. Therefore, this article conducts a detailed analysis and systematic summary of the application guidance of the phenomenon of glass transition in the preparation process, and its influence on the preparation intermediates and products, so as to provide theoretical guidance for preparation production and product storage.
