The research progress on the structure pharmaceutics and dosage form structures of traditional Chinese medicines

Ting Yang; Zhe LI; Dao-ming Feng; Ying Zhang; Jing LI; Hui-peng XU; Wen-ting WU; Li WU; Xian-zhen Yin; Wei-feng Zhu; Ji-wen Zhang

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The research progress on the structure pharmaceutics and dosage form structures of traditional Chinese medicines

VernacularTitle:结构药剂学与中药制剂结构研究进展
Author: Ting YANG ^{1
,

2
,

3} ; Zhe LI ⁴ ; Dao-ming FENG ^{1
,

2} ; Ying ZHANG ¹ ; Jing LI ¹ ; Hui-peng XU ¹ ; Wen-ting WU ⁴ ; Li WU ^{1
,

2} ; Xian-zhen YIN ^{1
,

2} ; Wei-feng ZHU ⁴ ; Ji-wen ZHANG ^{1
,

2
,

3}
Author Information

1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2. Jiangxi University of Chinese Medicine, Nanchang 330004, China
3. Nanjing University of Chinese Medicine, Nanjing 210023, China
4. Jiangxi University of Chinese Medicine, Nanchang 330004, China
Publication Type:Research Article
Keywords: structure pharmaceutics; traditional Chinese medicine preparation; imaging; three dimension; quality evaluation
From: Acta Pharmaceutica Sinica 2021;56(8):2070-2085
CountryChina
Language:Chinese
Abstract: Traditional Chinese medicine (TCM) preparations have made tremendous progresses in modernization, whereas there exist relatively few researches pertaining to preparation structures. As demonstrated by the theory and practice of structure pharmaceutics, the structure properties of dosage forms have significant influences on the quality and efficacy of drugs, which might offer reference for the research and development of TCM dosage forms. With the application of synchrotron radiation X-ray micro-computed tomography (SR-μCT) and other novel technologies in recent years, researches in structure pharmaceutics have made huge advancement, which provide reference and methodology basis for the study of TCM preparations. The article generalized and summarized the recent progresses and methods in the structure researches of pharmaceutics and TCM preparations, and further explored the significance of the researches of structure of TCM preparations. It is expected to provide the basis for the dosage form design, production process improvement, and quality evaluation of TCM and promote the modernization of TCM preparations.