Research progress and thinking on improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine based on crystal structure
10.16438/j.0513-4870.2021-0813
- VernacularTitle:基于药物晶型结构改善中药活性成分理化特性与功效的研究进展与思考
- Author:
Ying-chong CHEN
;
Wei-cheng ZHOU
;
Fang-fang LEI
;
Li-zhen HUANG
;
Qin ZHENG
;
Ming YANG
;
Peng-fei YUE
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
active ingredient;
crystal structure;
physicochemical property;
efficacy
- From:
Acta Pharmaceutica Sinica
2021;56(8):2059-2069
- CountryChina
- Language:Chinese
-
Abstract:
The active ingredients in traditional Chinese medicine have been reported to possess significant pharmacological activity and played an important role in clinical treatments. However, lots of the active ingredients in traditional Chinese medicine suffer from disadvantages such as low solubility, high melting point and low stability that results in low bioavailability and limit its clinical application. Crystal structure plays an important role in improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine. This review concludes the research advances of several crystal forms used in the active ingredients in traditional Chinese medicine in terms of polymorph, cocrystal, amorphous/coamorphous and nanocrystal. And the effects of crystal forms on the physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine were reviewed. This research may be useful for the formulation preparation and development of the active ingredients in traditional Chinese medicine.
