Improving compactibility properties of Lonicera Japonica Flos by Plasdone S-630
10.16438/j.0513-4870.2021-0514
- VernacularTitle:共聚维酮改善金银花粉末压缩成型性能的研究
- Author:
Wen ZHANG
1
;
Ya-ting YU
1
;
Li-jie ZHAO
1
;
Jun-hong ZHANG
2
;
You-jie WANG
1
;
Lan SHEN
3
;
Ruo-fei DU
1
;
Yan-long HONG
4
;
Yi FENG
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou 363000, China
3. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
4. Health Service Collaborative Innovation Center of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
italic>Lonicera Japonica;
particle modification;
fluidity;
compactibility;
fluid-bed technology
- From:
Acta Pharmaceutica Sinica
2021;56(8):2127-2135
- CountryChina
- Language:Chinese
-
Abstract:
To improve the fluidity and compactibility properties of raw powders of traditional Chinese medicine by particle modification technology, Lonicera Japonica Flos was used as a model drug, fluidized bed bottom spray technology was used, and Plasdone S-630 was used as a modifier to prepare modified particles. The powder properties, tablet compactibility parameters, disintegration time and dissolution were measured. The surface morphology of the powder particles before and after modification and compressed tablets were characterized by combining with scanning electron microscopy technology. The results showed that the particle size of Lonicera Japonica powder has been increased after particle modification, the fluidity, compressibility and compactibility of the powder have been improved to some extent, the disintegration time has also been reduced, and the dissolution in vitro is not affected. Therefore, this study can provide reference and ideas for the common problem that raw powder of traditional Chinese medicine that cannot meet the needs of preparation production due to poor powder properties such as fluidity and compressibility.
