Secondary metabolites of endophyte Alternaria sp. W-1 from Laminaria japonica
10.16438/j.0513-4870.2021-0488
- VernacularTitle:海带内生菌Alternaria sp. W-1次生代谢产物研究
- Author:
Sha-sha WANG
1
,
2
;
Xi CHEN
3
;
Feng-wu WANG
4
;
Ya-ping XU
1
,
2
;
Tong YE
1
,
2
;
Li SHEN
1
,
2
Author Information
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China
3. Yangzhou Hospital of TCM, Yangzhou 225001, China
4. College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
- Publication Type:Research Article
- Keywords:
italic>Laminaria japonica;
endophyte;
italic>Alternaria sp.;
secondary metabolite;
tricycloalternarene compound
- From:
Acta Pharmaceutica Sinica
2021;56(8):2248-2251
- CountryChina
- Language:Chinese
-
Abstract:
Six compounds were isolated from the crude extract of the liquid culture of Alternaria sp. W-1 by silica gel column chromatography, Sephadex LH-20 gel column chromatography, and HPLC. They were identified as 6-iso-tricycloalternarene 6a (1), tricycloalternarene 6a (2), tricycloalternarene B (3), uracil (4), 5-methyluracil (5), and lumichrome (6) through HR-MS, NMR and literature comparison. 6-iso-Tricycloalternarene 6a (1) is a new compound which has never been reported in the literature. In cytotoxicity assay, compounds 1-3 showed weak inhibition activity to human hepatoma cell line SMMC-7721 and human gastric cell line SGC-7901.
