Research advances on the effect of ginsenoside Rg1 on angiogenesis and vascular protection
10.16438/j.0513-4870.2021-0107
- VernacularTitle:人参皂苷Rg1促血管生成及其血管保护作用研究进展
- Author:
Yan-tao YANG
1
,
2
,
3
;
Yan YANG
1
,
2
,
3
;
Jia-mei XIAO
1
,
2
;
Nai-hong CHEN
1
,
3
,
4
Author Information
1. Pharmacy School, Hunan University of Chinese Medicine, Changsha 410208, China
2. Druggability and Preparation of Chinese Medicine Key Laboratory of Hunan Province, Changsha 410208, China
3. Center for Standardization and Functional Engineering of Traditional Chinese Medicine in Hunan Province, Changsha 410208, China
4. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
ginsenoside Rg1;
miRNA;
endothelial cell;
preparation material;
angiogenesis
- From:
Acta Pharmaceutica Sinica
2021;56(8):2146-2153
- CountryChina
- Language:Chinese
-
Abstract:
Ginsenoside Rg1 is one of the most important active components of the "king of herbs" Panax ginseng, which is an important angiogenic protective agent. The research results have shown that Rg1 has a wide range of cardiovascular pharmacological effects in vivo and in vitro, mainly through promoting the proliferation of smooth muscle cells, inhibiting endothelial cell aging, antioxidant stress, inhibiting inflammatory response, activating key factors of angiogenesis, improving vasodilation and other ways. Many miRNAs participate in the process of Rg1 promoting angiogenesis, mediate the regulation of the specific expression of downstream related targets to promote angiogenesis and vascular remodeling, and have the potential to become new clinical biomarkers and therapeutic targets. New preparation technologies and materials are used to make up for the weakness of Rg1's blood-brain barrier permeability, and further promote and enrich the clinical application of Rg1.
