Progress on the application of artificial intelligence technology in ligand-based and receptor structure-based drug screening
10.16438/j.0513-4870.2021-0052
- VernacularTitle:人工智能在基于配体和受体结构的药物筛选中的应用进展
- Author:
Run-zhe LIU
;
Jun-ke SONG
;
Ai-lin LIU
;
Guan-hua DU
- Publication Type:Research Article
- Keywords:
artificial intelligence;
virtual screening;
computer aided drug design;
pharmacology
- From:
Acta Pharmaceutica Sinica
2021;56(8):2136-2145
- CountryChina
- Language:Chinese
-
Abstract:
Artificial intelligence technology is being widely applied in drug screening. This paper introduces the characteristics of artificial intelligence, and summarizes the application and progress of artificial intelligence technology especially deep learning in drug screening, from ligand-based and receptor structure-based aspects. This paper also introduces how to apply artificial intelligence to drug design from these two aspects. Finally, we discuss the main limitations, challenges, and prospects of artificial intelligence technology in the field of drug screening.
