Research progress of plant-derived vesicles and their biomedical applications
10.16438/j.0513-4870.2020-1514
- VernacularTitle:植物来源囊泡及其生物医学应用研究进展
- Author:
Meng ZHAO
1
;
Si-min LI
1
;
Lei ZHANG
1
;
Ming-hui CONG
1
;
Li-hong HU
1
;
Hong-zhi QIAO
1
,
2
Author Information
1. Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
extracellular vesicle;
exosome;
nanoparticle;
plant;
Chinese medicine;
pharmacological action;
rug delivery;
structural Chinese medicine;
pharmacodynamic substance basis
- From:
Acta Pharmaceutica Sinica
2021;56(8):2039-2047
- CountryChina
- Language:Chinese
-
Abstract:
Plant-derived extracellular vesicles (EVs) are membranous vesicles secreted by plants, which include lipid bilayer as the basic framework and encapsulate various proteins, nucleic acid and other active substances. They play an important role in plant growth and development, tissue repair and self-defense. In recent years, extracellular vesicle-like nanoparticles (EVNs) are prepared from plant samples referring to the separation method of EVs and show unique functions. In this review, the above structures are collectively called plant-derived vesicles (PDVs). The biogenesis, separation and characterization methods, in vivo and in vitro properties of PDVs have been reviewed. The biomedical applications of PDVs as natural therapeutic agents and functional drug carriers are described, and finally some opinions on the existing problems and future prospect in this field are put forward.
