Metabolism characteristics and pharmacological insights of flavonoids based on the intestinal bacteria
10.16438/j.0513-4870.2021-0625
- VernacularTitle:基于肠道菌的黄酮类成分代谢特征及药理学思考
- Author:
Hang YU
1
;
Rui-fang ZHENG
2
;
Wen-ling SU
2
;
Jian-guo XING
2
;
Yan WANG
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Xinjiang Institute of Materia Medica, Urumqi 830004, China
- Publication Type:Research Article
- Keywords:
rug metabolism;
flavonoids;
gut microbiota;
gut microbiota metabolites;
natural medicine
- From:
Acta Pharmaceutica Sinica
2021;56(7):1757-1768
- CountryChina
- Language:Chinese
-
Abstract:
The gut microbiota takes part in many in vivo important physiological activities of host, such as the substance metabolism and energy exchange, etc. The interaction between the host and the intestinal microorganisms has attracted scholars' attention. Flavonoids are a group of polyphenol compounds widely found in natural plants, with the bioactive effect of regulation of glucose and lipid metabolism, anti-inflammation. However, their low bioavailability cause difficulty to clarify the effective substances and the mechanism of flavonoids. Apart from the metabolic effects of liver on flavonoids, recent studies have shown that the gut microbiota can interact with flavonoids. On the one hand, flavonoids can be metabolized by gut microbiota and subsequent metabolites can produce pharmacological activities different from the parent components. On the other hand, flavonoids and their metabolites can in turn regulate the composition and physiological activities of the intestinal flora, which seems to provide a new insight for the research on the effective substances of flavonoids. In this review, we introduced the metabolic characteristics of flavonoids under the actions of intestinal bacteria, and the regulation effects of flavonoids on gut microbiota was also summarized. Meanwhile, the therapeutic effect of flavonoids under the action of intestinal bacteria was discussed.
