Research progress on the traditional Chinese medicine-pharmaceutical drug interaction mediated by the ABC transporter family
10.16438/j.0513-4870.2021-0605
- VernacularTitle:ABC转运蛋白家族介导的中药-化药相互作用研究进展
- Author:
Yu-zhen HE
;
Hui WANG
;
Jia-hao FANG
;
Yu-hong CAO
;
Zhan-ying HONG
;
Yi-feng CHAI
- Publication Type:Research Article
- Keywords:
ATP binding cassette-transporter;
traditional Chinese medicine-chemical medicine interaction;
intestinal barrier;
blood-brain barrier;
multi-drug resistance
- From:
Acta Pharmaceutica Sinica
2021;56(7):1778-1788
- CountryChina
- Language:Chinese
-
Abstract:
ABC transporters on the intestinal barrier, blood-brain barrier and on tumor cells will affect drug bioavailability, transport across the blood-brain barrier and multidrug resistance. The active ingredients of traditional Chinese medicines can affect the function and expression of ABC transporters. When combined with pharmaceuticals the potential interaction between the two can change the efficacy of the medicines. We review the ABC transporter superfamily and their distribution with regard to their relationship and interactions with traditional Chinese medicine on the intestinal barrier and the blood-brain barrier, as well as their role in tumor multidrug resistance mediated by ABC transporters. We summarize the research progress over the past five years.
