Research progress of natural drugs targeting mitochondrial autophagy against ischemic heart disease
10.16438/j.0513-4870.2021-0184
- VernacularTitle:线粒体自噬为靶点的抗缺血性心脏病天然药物研究进展
- Author:
Di-fei GONG
;
Lian-hua FANG
;
Guan-hua DU
- Publication Type:Research Article
- Keywords:
ischemic heart disease;
mitochondrial autophagy;
natural drug;
signaling pathway;
rug target
- From:
Acta Pharmaceutica Sinica
2021;56(7):1872-1879
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic heart disease (IHD), which has been considered to be exclusively caused by stenosis or occlusion of coronary artery, is a significant cause of morbidity and mortality worldwide. Mitochondrial dysfunction is the main pathological basis of ischemic heart disease and reperfusion injury, and moderate mitochondrial autophagy can selectively remove damage proteins and organelles to maintain intracellular homeostasis, so mitochondrial autophagy is important for maintaining the homeostasis of cardiomyocytes. Natural drugs from plants are widely used in ischemic heart disease. In recent years, more and more natural drugs have been proven to alleviate myocardial cell damage after ischemia/reperfusion through mitochondrial autophagy. This paper reviews the research progress of natural drugs from plants medicines regulating mitochondrial autophagy in the treatment of ischemia heart disease.
