Application and mechanism of nanomedicine in antifungal infection therapy
10.16438/j.0513-4870.2021-0053
- VernacularTitle:纳米药物递释系统在抗真菌感染治疗中的应用及机制
- Author:
Shui-sheng CHEN
1
;
Ke-qian ZHOU
2
;
Xiao-dong LI
1
;
Quan-zhen LÜ
1
;
Yuan YU
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China
2. Anesthesiology Department, Naval Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
fungal disease;
antifungal agent;
rug resistance;
nanomedicine;
biomaterial
- From:
Acta Pharmaceutica Sinica
2021;56(7):1893-1901
- CountryChina
- Language:Chinese
-
Abstract:
The threat of fungal diseases is increasingly rigorous. The clinically invasive fungal infections remain a main cause of morbidity and mortality in certain high-risk groups, especially in critical patients or immunocompromised patients. In drug therapy, the problems of off-target toxicity and antifungal drug resistance are still challenging. With the wide application of biomaterials and nanotechnology, more nanomedicine studies have been carried out on antifungal drugs, such as the amphotericin B liposome which greatly reduced the renal toxicity of drugs has been successfully marketed. For the unique physical and chemical properties, the nano-drug delivery system possessed great potential in improving the bioavailability, reducing the side effects of drugs, increasing the stability of drugs, and achieving cells or tissue-specificity through the modification. This review summarized the applications and limitations of antifungal drugs. Some nanomedicines were summarized in discussion oriented around the antifungal therapy, including liposomes, niosomes, lipid nanoparticles, polymer nanoparticles, microemulsion, dendrimers, inorganic nanocarriers. Nanotechnology and nano-drug delivery system provide promising strategies for the research and development of new formulations that can improve antifungal activity and possibly overcome antifungal drug resistance.
