Research progress of effective components of traditional Chinese medicine in anti-aging and anti-tumor mechanism
10.16438/j.0513-4870.2021-0035
- VernacularTitle:中药有效成分在抗衰老与抗肿瘤作用机制中的研究进展
- Author:
Ruo-yu ZHOU
1
,
2
;
Man-ting SUN
3
;
Jing LIU
3
;
Ying LUO
1
,
2
Author Information
1. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
2. Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China
3. Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
effective component;
anti-aging effect;
anti-tumor activity;
cellular signaling pathway
- From:
Acta Pharmaceutica Sinica
2021;56(7):1856-1864
- CountryChina
- Language:Chinese
-
Abstract:
Increasing research have found a high correlation between senescence and tumor. Cellular senescence can inhibit tumorigenesis while the cellular microenvironment altered by senescent cells can promote the proliferation and metastasis of tumor cells. Some cellular signaling pathways are commonly involved in aging process and carcinogenesis. The deregulation and imbalance of these pathways results into senescence and tumor development. Thus, agents that balance these pathways may effective for anti-aging and anti-tumor. Traditional Chinese medicine (TCM) has been used for the activation of multiple signaling pathways and molecular targets both associated with aging and tumor, with few side effects. Therefore, the article reviewed the cellular signalings that cross between the aging and tumors, and on this basis, summarized the current effective components of TCM with anti-aging and anti-cancer properties, as well as the potential mechanisms of these components in the cross signalings, to provide new research strategies and perspectives for effective components of TCM to treat aging and tumors.
