Research progress of antioxidant drugs in myocardial ischemia-reperfusion injury

VernacularTitle:抗氧化药物在心肌缺血再灌注损伤中的研究进展
Author: Jing-wen XIE ^{1
,

2} ; Tian-de SU ³ ; Yu-ting WEI ¹ ; Ge LI ³ ; Jian-zhang WU ³ ; Li-li HUANG ⁴
Author Information

1. Department of Pharmacy, the First People's Hospital of Wanzhou District, Chongqing 404040, China
2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
3. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
4. Department of Pharmacy, Lihuili Hospital Affiliated to Ningbo University, Ningbo 315040, China
Publication Type:Research Article
Keywords: myocardial ischemia-reperfusion injury; antioxidant; free radical; oxidative stress; mechanism
From: Acta Pharmaceutica Sinica 2021;56(7):1845-1855
CountryChina
Language:Chinese
Abstract: Myocardial ischemia-reperfusion injury (MIRI) is one of the most difficulties in the studies of cardiovascular diseases, and excessive reactive oxygen species (ROS) accumulation in cells is the main cause of it. Reducing ROS level by antioxidant drugs to protect cardiomyocytes is being the spotlight on MIRI treatment. In this review, the research progress of antioxidant drugs in myocardial ischemia-reperfusion injury in recent years was summarized.