A new dimeric dehydrocorydaline alkaloid from vinegar-prepared Corydalis yanhusuo
10.16438/j.0513-4870.2021-0121
- VernacularTitle:醋制延胡索中一个新的原小檗碱型二聚体生物碱
- Author:
Dong-jie FANG
1
;
Gui-yang XIA
2
;
Ling-yan WANG
1
;
Huan XIA
2
;
Yan-bin SUN
1
;
Sheng LIN
1
,
3
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
italic>Corydalis yanhusuo;
imeric alkaloid;
protoberberine;
anti-inflammatory
- From:
Acta Pharmaceutica Sinica
2021;56(4):1096-1099
- CountryChina
- Language:Chinese
-
Abstract:
Bidehydrocorydaline A (1), a new dimeric alkaloid of proberberine connected by a methylenedioxy group, was isolated from the vinegar-prepared Corydalis yanhusuo by various chromatographic methods, including column chromatography over macroporous adsorption resin and silica gel, reverse-phase MPLC, and semi-preparative HPLC. Its structure was determined by spectroscopic methods, including UV, IR, HR-ESI-MS, 1D and 2D NMR. Bidehydrocorydaline A (1) showed potent inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages, with an IC50 value of 2.33 ± 0.57 μmol·L-1.
