Strategies and reflections on platelet-based targeted therapy for tumor
10.16438/j.0513-4870.2020-1903
- VernacularTitle:基于血小板的肿瘤靶向治疗策略与反思
- Author:
Xiao-xue LAI
;
Shuo WANG
;
Xin-yang YAN
;
Xin-rong LIU
;
Yan-zhi SONG
;
Yi-hui DENG
- Publication Type:Research Article
- Keywords:
platelet;
neoplasm;
rug delivery system;
molecular targeted therapy;
platelet activation;
early detection of cancer
- From:
Acta Pharmaceutica Sinica
2021;56(4):1025-1034
- CountryChina
- Language:Chinese
-
Abstract:
In the past few decades, our understanding of platelets has made great progress. Platelets play an unexpected central role in cancer and greatly affect the behavior of cancer cells. At the same time, the physiology and phenotype of platelets are also affected by cancer cells. Therefore, platelet-based tumor targeted therapy strategies have attracted the attention of researchers, but the limitations of their application require more attention. In this paper, the strategies of platelet-based tumor targeted therapy are summarized, and the strategies of platelet mimicking nanocarrier delivery, platelet hitch riding, platelet membrane coating biomimetic and engineered platelet targeting are mainly introduced. The easy activation, hard storage and unknown functional and phenotypic changes of platelets were discussed. At the same time, the strategy of platelet-based targeted tumor therapy is reviewed from theoretical basis and practical application. The development potential of platelets in the field of tumor diagnosis and treatment is discussed, which will provide some theoretical reference for the study of platelet-related tumor diagnosis and targeted therapy.
