Interferon-regulatory factors regulate macrophage polarization and its role in diseases
10.16438/j.0513-4870.2020-1773
- VernacularTitle:干扰素调节因子调控巨噬细胞极化及其在疾病中的作用研究进展
- Author:
Shu-shu HAO
1
,
2
;
Chen-chen JIANG
1
;
Li-li FENG
1
Author Information
1. Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China
2. School of Stomatology, Nanjing Medical University, Nanjing 211166, China
- Publication Type:Research Article
- Keywords:
interferon regulatory factor;
macrophage polarization;
inflammatory disease;
rug target
- From:
Acta Pharmaceutica Sinica
2021;56(4):939-948
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are highly plastic and heterogeneous. In different types of inflammatory diseases, or at different stages of the same disease, macrophages can undergo phenotypic transformation to elicit different functions. Hence, exploring new regulatory mechanism of macrophage polarization and seeking for new key mediators will lay the foundation for the diagnosis and treatment of macrophage-related diseases, such as inflammatory diseases, autoimmune diseases, and cancer. Interferon regulatory factors (IRFs) have been reported to play an important role in the maturation and differentiation of macrophages. In this review, we will describe the structure and modulation pattern of IRFs, and then further summarize the molecular mechanism and signal regulation network of IRFs in pathological processes of related diseases through controlling macrophage polarization. Our review will explore the new therapeutic strategy and potential drug targets for related diseases.
