Research progress of aristolochic acids and their biomarkers
10.16438/j.0513-4870.2020-1719
- VernacularTitle:马兜铃酸类物质的生物标记物与减毒策略研究进展
- Author:
Ning GUO
1
,
2
;
Yong ZHAO
1
;
Yi SUN
1
;
An-qi WANG
1
;
Ling-chuan XU
3
;
Ai-hua LIANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
3. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
- Publication Type:Research Article
- Keywords:
aristolochic acid;
toxicity;
biomarker;
attenuation
- From:
Acta Pharmaceutica Sinica
2021;56(4):972-982
- CountryChina
- Language:Chinese
-
Abstract:
Aristolochic acids (AAs) are widely distributed in Aristolochiaceae, and are important toxic components in medicinal plants of Aristolochiaceae. As one of the most powerful carcinogens in the Carcinogenic Potency Database (CPDB), AAs can induce hepatotoxicity, nephrotoxicity, carcinogenicity, mutagenicity, and other adverse reaction. AAs also can produce a series of metabolites such as AA-DNA adducts in the body, and their specific metabolites can be used as biomarkers for early diagnosis and treatment of related diseases. Thus, the current discovery for technical means that can quickly and accurately detect biomarkers possesses significant research value. AAs can be attenuated by processing, compatibility, molecular breeding, and other methods to improve the clinical safety of Chinese medicine containing AAs. In this review, we report the distribution of AAs, attenuation strategies and biomarker detection. We would like to provide a reference for the quality control of AAs-containing Chinese medicines, as well as for the prevention and control of diseases caused by AAs.