Evaluation of non-clinical anxiety disorder models
10.16438/j.0513-4870.2020-1569
- VernacularTitle:抗焦虑障碍药物非临床药效学评价体系探索
- Author:
Jia-qi LAN
1
;
Chun-yang ZHAO
2
;
Lei WU
1
;
Xin-hong FENG
3
;
Qing-li WANG
2
;
Ying PENG
1
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China
3. Department of Neurology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, China
- Publication Type:Research Article
- Keywords:
anxiety disorder;
animal model;
behavioristics;
non-clinical pharmacodynamics;
rug discovery
- From:
Acta Pharmaceutica Sinica
2021;56(4):949-965
- CountryChina
- Language:Chinese
-
Abstract:
Anxiety disorders are one of the most common mental disorders in adults, the cause of which derives from a combination of genetics and environmental factors. A series of animal models have been established according to their pathogenesis to measure the level of anxiety or induce anxiety only, and these models have been widely applied in the non-clinical evaluation of anxiolytics. In this review, we present the current trends in the study of anxiety disorders and summarize typical non-clinical anxiety animal models, including models that both measure anxiety levels and induce anxiety, and models that induce anxiety only. This review summarizes the important issues in standardized non-clinical research of anxiety disorders and proposes criteria for the selection of an appropriate R&D model.