Recent advances of MDM2-p53 inhibitors
10.16438/j.0513-4870.2020-1454
- VernacularTitle:MDM2-p53抑制剂的研究进展
- Author:
Ji-chao WANG
;
Cai-bin YANG
;
Yi-lin ZHUO
;
Chong LIANG
;
Jun-gang WANG
;
Sheng DONG
;
Bo-teng LI
;
Shu-hua ZHANG
;
Guo-gang ZHANG
- Publication Type:Research Article
- Keywords:
protein-protein interaction;
MDM2-p53;
inhibitor;
recent advance;
clinical study
- From:
Acta Pharmaceutica Sinica
2021;56(4):983-995
- CountryChina
- Language:Chinese
-
Abstract:
Protein-protein interactions (PPI) are involved in a variety of biological processes, including cell-to-cell interactions, metabolism and development control. The misregulation, post-translational modification and interference of PPI are related to a variety of human diseases, making the regulation of these interactions a very attractive field of drug discovery. In recent years, the interaction between MDM2 and p53 has become a research hotspot, which plays an important role in the treatment of tumors. But unfortunately there are no such inhibitors approved all over the world. In this view, recent advances of MDM2-p53 inhibitors were briefly described and its inhibitors with potential therapeutic activities in clinical studies were introduced.
