Analysis of the research status and intervention strategies for the treatment of hepatic encephalopathy based on gut microbiota regulation
10.16438/j.0513-4870.2020-1222
- VernacularTitle:通过调控肠道菌群治疗肝性脑病的研究现状及治疗策略分析
- Author:
Jia-ting YIN
;
Yin PENG
;
Wen-hao XU
;
Meng-fei MAO
;
Jin-ao DUAN
;
Jian-ming GUO
- Publication Type:Research Article
- Keywords:
gut microbiota;
hepatic encephalopathy;
therapy;
pathogenesis;
hyperammonemia
- From:
Acta Pharmaceutica Sinica
2021;56(4):895-905
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic encephalopathy is a common metabolic neuropsychiatric syndrome in the development of end-stage liver disease. Since the concept of intestinal-liver-brain axis was proposed, the relationship between the pathogenesis of hepatic encephalopathy and the gut microbiota has been a hot research topic. In recent years, studies have confirmed that gut microbiota is involved in and affects various pathological processes of hepatic encephalopathy. This article combines the latest research progress at home and abroad to elaborate on the research status of regulating gut microbiota and thus interfering with the pathological process of hepatic encephalopathy, hoping to provide new ideas and methods for the intervention of hepatic encephalopathy based on the regulation of gut microbiota.
