Multi-compound pharmacokinetic research on Chinese herbal medicines: identifying potentially therapeutic compounds and characterizing their disposition and pharmacokinetics
10.16438/j.0513-4870.2021-0839
- VernacularTitle:中药多成分药代动力学: 发现与中药安全性和有效性关联的物质并揭示其药代特征
- Author:
Chuan LI
;
Chen CHENG
;
Wei-wei JIA
;
Jun-ling YANG
;
Xuan YU
;
Olajide E. OLALEYE
- Publication Type:Research Article
- Keywords:
Chinese herbal medicines;
multi-compound pharmacokinetic research;
bioavailability;
systemic exposure;
colon-luminal exposure;
isposition;
access to target of action
- From:
Acta Pharmaceutica Sinica
2021;56(9):2426-2446
- CountryChina
- Language:Chinese
-
Abstract:
Chinese traditional medicine has provided, since ancient times, a basis for health care and medicine to the Chinese nation and for China's national stability. Identification of the constituents responsible for therapeutic and undesired effects of Chinese herbal medicines is a type of key research facilitating the modernization of these medicines. For a complex Chinese herbal medicine, multi-compound pharmacokinetic research is a useful approach to identifying its constituents that are bioavailable (in their unchanged and/or metabolized forms) at loci responsible for the medicine's therapeutic action and to characterizing the compounds' disposition and pharmacokinetics related to the action. In addition, such pharmacokinetic research is also useful for identifying herbal compounds associated with the medicine's adverse effects and drug-drug interaction potential. Over the past decade, great advances have been achieved in the theory, methodology, associated techniques, and their application of such multi-compound pharmacokinetic research, which has become an emerging field in pharmacokinetics. In this perspective, we elaborate on the methodology, technical requirements, and key analytical techniques of multi-compound pharmacokinetic research on Chinese herbal medicines, describe research examples regarding investigation of pharmacokinetics and disposition of a class of bioactive herbal constituents (ginsenosides of Panax notoginseng root) and pharmacokinetics-based identification of potential therapeutic compounds from a dosed Chinese herbal medicine (LianhuaQingwen capsule), and discuss follow-up development for the multi-compound pharmacokinetic research.
