Application of nano-bionic drug delivery system based on macrophages in tumor therapy
10.16438/j.0513-4870.2021-0669
- VernacularTitle:基于巨噬细胞的纳米仿生递药系统在肿瘤治疗中的应用
- Author:
Jin-hu LIU
;
Yong-jun LIU
;
Na ZHANG
- Publication Type:Research Article
- Keywords:
macrophage;
nano-carrier;
nano-bionic drug delivery system;
tumor therapy;
cell therapy
- From:
Acta Pharmaceutica Sinica
2021;56(9):2505-2512
- CountryChina
- Language:Chinese
-
Abstract:
The construction of nano-bionic drug delivery system based on cells or cellular components is a research hotspot of novel drug delivery systems at present. The nano-bionic drug delivery system can integrate the characteristics not only high drug loading and controlled release of nano-carriers, but also good biocompatibility, low immunogenicity and natural targeting from bionic components of cell, and it can also integrate with flexible morphology from living cells. Among them, nano-bionic drug delivery system based on macrophages possesses a good prospect of clinical application because of phagocytic function, inherent tendency, deep penetration ability and potential in cell therapy of macrophages in the treatment of tumors. Based on this, this paper reviews the drug loading strategies of nano-bionic drug delivery system based on macrophages and its application in tumor therapy, so as to provide reference for the development of novel drug delivery systems.
