Lipid metabolism and hematological malignancies
10.16438/j.0513-4870.2021-0030
- VernacularTitle:脂质代谢与血液肿瘤
- Author:
Yi-chen LIU
;
Ting-ting DU
;
Qing-hua WANG
;
Zhi-hui ZHANG
;
Xiao-guang CHEN
- Publication Type:Research Article
- Keywords:
lipid metabolism;
fatty acid oxidation;
metabolic enzyme;
hematological malignancy
- From:
Acta Pharmaceutica Sinica
2021;56(9):2456-2463
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening of research in recent years, tumor metabolic reprogramming has gradually become the focus of research, and targeting tumor cell metabolism has also become a new means of tumor therapy. The metabolic process affects almost all the physiological processes of the organism, and lipid metabolism is an important part of the metabolic process. Studies have shown that changes in lipid uptake, storage and fatty acid synthesis and decomposition have occurred in a variety of tumors. Abnormal lipid metabolism will promote the rapid proliferation of tumors. Abnormal expression of a variety of key metabolic enzymes in the process of lipid metabolism is the key to tumor progression. The purpose of this paper is to explain the metabolic regulation of lipid metabolism and related metabolic enzymes in hematological tumors, and to provide ideas for the treatment of hematological tumors.
