Optimization of the Formulation of Curcumin Transethosomes
- VernacularTitle:姜黄素醇传递体处方的优化
- Author:
Xiaoshan LI
1
;
Kaitong LI
1
;
Sandi JIN
1
;
Qiaohong HU
1
Author Information
1. School of Pharmacy，Guangdong Pharmaceutical University/ Guangdong Engineering & Technology Research Center of Local Precision Drug Delivery System，Guangzhou 510006，China
- Publication Type:Journal Article
- Keywords:
Curcumin;
Transethosomes;
HPLC;
Box-Behnken design-response surface method;
Formulation optimization
- From:
China Pharmacy
2021;32(19):2383-2387
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To optimize the formulation of Curcumin （CUR）transethosomes（CUR-TEs）. METHODS ：The contents of CUR in CUR-TEs were determined by HPLC. CUR-TEs were prepared by injection method. Using comprehensive score of encapsulation efficiency and drug loading as index ，based on signal factor test ，Box-Behnken design-response surface method was used to optimize and validate the formulation. The property of CUR-TEs prepared by the optimal formulation was investigated. RESULTS：The optimal formulation of CUR-TEs was as follows as lecithin of 4％，CUR of 0.13％，1，2-propylene glycol of 25％，tween-80 of 1％. Results of validation test of optimal formulation showed that comprehensive score of encapsulation efficiency and drug loading of CUR-TEs was 93.04±2.16，relative error of which to predicted value （91.19）was 2.03％. The encapsulation efficiency of CUR-TEs prepared by optimal formulation was （91.17±1.35）％，and its drug loading was （0.94± 0.02）％. The particle size was （190.64±15.97）nm with polydispersity index of 0.086±0.007，and Zeta potential was （－12.74± 1.60）mV. CONCLUSIONS ：The optimized formulation of CUR-TEs is stable ，feasible and repeatable ，with good stability.
