Analysis of related risk factors of pulmonary hypertension in patients with COPD in high altitude area
10.3969/j.issn.1006-2483.2021.05.031
- VernacularTitle:高原地区慢性阻塞性肺疾病患者肺动脉高压的相关危险因素
- Author:
Lina CHEN
1
;
Baobao LIU
2
Author Information
1. Department of Cardiology, Qinghai Cardiovascular and Cerebrovascular Disease Hospital , Xining 810000 , China
2. Second Department of Coronary Heart Disease, Qinghai Cardiovascular and Cerebrovascular Disease Hospital , Xining 810000 , China
- Publication Type:Journal Article
- Keywords:
High altitude area;
Chronic obstructive pulmonary disease;
Pulmonary hypertension;
Risk factors
- From:
Journal of Public Health and Preventive Medicine
2021;32(5):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics and risk factors of pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) in plateau areas. Methods To select 562 COPD patients in Qinghai Plateau from January 2017 to December 2020 in the Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital. The patients were divided according to pulmonary artery systolic pressure (PASP) pulmonary hypertension (PH) group (PASP≥40mmHg) and non-pulmonary hypertension (NPH) group (PASP<40mmHg). The basic characteristics of the two groups of patients were compared, and multivariate logistic regression analysis was used to explore the related factors affecting pulmonary hypertension in COPD patients. Results Among the 562 COPD patients, the total incidence of PH was 29.89% (168/562). Among them, the incidence of PH in patients with grade I COPD was 16.16%, which was significantly lower than that of COPD patients with grade II (34.40%) and grades III to IV (43.86%), and the difference was statistically significant (χ2=30.848, P＜0.001). The percentage of forced expiratory volume in one second (FEV1%), blood oxygen saturation, B-type natriuretic peptide, mean platelet volume (MPV) in the PH group were different from those of NPH group (P<0.05). Multivariate logistic regression analysis showed that FEV1% [OR=1.082 (95%CI: 1.038-1.256)], MPV [OR=1.696 (95%CI: 1.273-2.257)] were risk factors for COPD patients with PH in high altitude areas (P<0.05). Conclusion The incidence of PH is higher in COPD patients in plateau areas, and COPD patients with lower FEV1% and higher MPV are more likely to develop PH.
