Epidemiology and pathogen composition of enterovirus in children with hand, foot and mouth disease in Guangyuan, Sichuan
10.3969/j.issn.1006-2483.2021.05.025
- VernacularTitle:四川广元地区手足口病儿童肠道病毒流行病学及病原学分析
- Author:
Yan XIANG
1
;
Liang CHEN
1
;
Tianrong LONG
1
;
Kebo ZHANG
1
Author Information
1. Laboratory of Guangyuan Mental Health Center, Guangyuan, Sichuan 628000 , China
- Publication Type:Journal Article
- Keywords:
Guangyuan area;
Hand, foot and mouth disease;
Enterovirus in children;
Epidemiology;
Etiology
- From:
Journal of Public Health and Preventive Medicine
2021;32(5):109-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the epidemiology and pathogenic characteristics of enterovirus in children with hand, foot and mouth disease (HFMD) in Guangyuan area, and to provide a basis for the development of HFMD prevention and control strategies. Methods A total of 759 children with HFMD clinically diagnosed in Guangyuan area from January 2019 to January 2021 were randomly selected. The seasonal, age, gender, regional distribution and pathogen distribution characteristics of HFMD were analyzed by descriptive epidemiological methods. Results The incidence of HFMD was seasonal and presented a typical bimodal distribution, with the summer peak occurring from April to July (χ2=8.714, P<0.05) and the winter peak from October to December (χ2=7.542, P<0.05). There was a significant difference in the incidence rate between regions, and the incidence rate in urban areas was much higher than that in rural areas (χ2=5.915, P<0.05). P < 0.05). The male-female incidence ratio was 1.63:1. The high incidence group of HFMD was children younger than 5 years old, and the number of reported cases was 730. The high incidence age group was 1-3 years old (χ2=8.455, P<0.05). The incidence rate of HFMD in all age groups ≤5 years old was higher in male than female, and the difference was statistically significant (χ2=5.174, P<0.05). A total of 388 HFMD cases were tested positive for viral nucleic acid, with a positive rate of 51.12%, In mild cases, Cox A16, EV71, and other enteroviruses accounted for 27.64%, 29.54% and 29.54%, respectively. The proportion of EV71 in severe cases was 89.47%. Conclusion HFMD is widely distributed in Guangyuan area, with obvious seasonal and population differences. The prevention and control of HFMD should be strengthened in key areas, high incidence seasons and key populations, and the vaccination of children ≤3 years old should be further promoted to prevent the outbreak of HFMD.
