Determination of the Contents of Heavy Metals and Harmful Elements in Pediatric ，Paracetamol，Atificial Cow- bezoar and Chlorphenamine Maleate Granules by ICP-MS
- VernacularTitle:ICP-MS法测定小儿氨酚黄那敏颗粒中重金属及有害元素的含量
- Author:
Shuang PENG
1
,
2
,
3
;
Haiyuan YANG
1
,
2
,
3
;
Minjuan ZHANG
1
,
2
,
3
;
Wenzhi WEI
1
,
2
Author Information
1. Qinghai Provincial Drug Inspection and Testing Institute，Xining 810016，China
2. NMPA Key Laboratory for Quality Control of TCM （Tibetan Medicine ），Xining 810016，China
3. Qinghai Provincial Key Laboratory of Modernization of Traditional Chine se and Tibetan Medicine，Xining 810016，China
- Publication Type:Journal Article
- Keywords:
Pediatric paracetamol artificial cow-bezoar and chlorphenamine maleate granules;
ICP-MS;
Heavy metals
- From:
China Pharmacy
2021;32(18):2218-2222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To es tablish a method for the content determination of heavy metals [lead （Pb），cadmium（Cd）， copper （Cu）， mercury （Hg）] and harmful elements [arsenic （As）] in Pediatric paracetamol artificial cow-bezoar and chlorphenamine maleate granules. METHODS ：The samples were conducted pretreatment by microwave digestion instrument and determined by inductively coupled plasma mass spectrometry （ICP-MS）using elements germanium ，indium，bismuth as internal standard. RESULTS ：The linear ranges of Pb ，As，Cu，Cd and Hg were 1-20，0.5-10，5-100，0.5-10 and 0.2-4 ng/mL， respectively （all r＞0.997）. The limits of detection （LODs） were 0.041 1，0.013 2，0.057 3，0.009 0，0.005 4 ng/mL， respectively. The limits of quantification （LOQs）were 0.137 0，0.044 0，0.191 0，0.030 0，0.018 0 ng/mL，respectively. RSDs of precision and repeatability tests were all less than 6％. RSDs of stability tests （28 h）of Pb ，As，Cu and Cd were all less than 5％， and that of stability test （28 h）of Hg was less than 7％. The average recoveries were 89.44％（RSD＝5.87％，n＝9），99.56％ （RSD＝5.46％ ，n＝9），96.12％（RSD＝4.62％ ，n＝9），105.82％（RSD＝2.80％ ，n＝9）and 90.23％（RSD＝3.59％ ，n＝9）， respectively. Five elements were all detected in 63 batches of samples ，and the contents of them were 0.191 0-1.527 6，0.002 5- 0.047 4，0.034 1-1.549 0，0.001 5-0.078 8 and 0.001 9-0.005 4 mg/kg，respectively. CONCLUSIONS ：The method is simple ， sensitive and accurate. It is suitable for simultaneous determination of 5 elements in Pediatric paracetamol artificial cow-bezoar and chlorphenamine maleate granules.
