Progress of researches on the role of neutrophil extracellular traps in the immune responses against parasites
10.16250/j.32.1374.2020187
- VernacularTitle:中性粒细胞胞外诱捕网在抗寄生虫免疫中的 作用研究进展
- Author:
Wen-Lin LI
1
;
Zhi-Wei XU
1
;
Shu-Ning LI
1
;
Hai-E SHEN
2
;
Yang WANG
2
;
Zhi-Min LI
3
;
Chen-Shuo ZHANG
2
;
Yang-Guang XING
2
;
Xin SHEN
2
Author Information
1. College of Clinical Medicine, North China University of Science and Technology, Tangshan 063210, China
2. College of Life Sciences, North China University of Science and Technology, China
3. College of Nursing and Rehabilitation, North China University of Science and Technology, China
- Publication Type:Journal Article
- Keywords:
Parasite;
Neutrophil;
Extracellular trap net;
Immune response
- From:
Chinese Journal of Schistosomiasis Control
2021;33(4):434-438
- CountryChina
- Language:Chinese
-
Abstract:
Neutrophil extracellular trap (NET) is a type of bead-like, fibrous and reticular substances that is actively released by activated inflammatory neutrophils during the stage of infections or inflammatory responses. NET, which is composed of chromatin DNA and multiple intracellular protein components, may wrap pathogens to limit their diffusions. Meanwhile, NET may kill pathogens via a wide range of antibacterial proteins, which is considered as the third antibacterial mechanism of neutrophils, in addition to phagocytosis and degranulation. Recent studies have shown the involvement of NET in the immune response against parasitic infections. This review summarizes the advances of NETs in the immune responses against parasitic infections, so as to provide insights into the elucidation of the pathogenesis and development of therapeutics of parasitic diseases.
