Effects and Mechanism of Jidesheng Anti-venom Tablet on Local Wound Inflammation and Systemic Inflammatory Response of Snake Bite Patients
- VernacularTitle:季德胜蛇药片对蛇咬伤患者创口局部和全身炎症反应的影响及机制
- Author:
Jie HU
1
;
Chaojin YANG
1
;
Xingsong HE
1
;
Zheng MING
1
;
Zhihui XIE
2
Author Information
1. First Dept. of ICU，the Affiliated Hospital of Zunyi Medical University，Guizhou Zunyi 563003，China
2. Emergency Department，the Affiliated Hospital of Zunyi Medical University，Guizhou Zunyi 563003，China
- Publication Type:Journal Article
- Keywords:
Jidesheng anti-venom tablet;
Snake bites;
Local wound inflammation;
Systemic inflammatory response
- From:
China Pharmacy
2021;32(17):2102-2107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To investigate the effects and mechanism of Jidesh eng anti-venom tablet on local wound inflammation and systemic inflammatory response of snake bite patients. METHODS ：Totally 64 patients with snake bite admitted to our hospital during Jun. 2018-Jun. 2020 were randomly divided into control group and observation group ，with 32 cases in each group. Both groups received routine treatment ，such as debridement ，drainage，flushing，sealing，anti-venom，anti-infection，anti-fibrinolysis and anti-shock. Observation group was additionally given Jidesheng anti-venom tablet for internal and external use ，for consecutive 7 d. Related indexes of systemic inflammatory response ，local wound condition ，hospital stay ，laboratory indexes of important organs，coagulation function index ，wound inflammatory cell counts ，serum levels of inflammatory cytokines and chemokine ，the occurrence of ADR were compared between 2 groups. RESULTS ：After treatment ，most of related indexes of systemic inflammatory response （RR，HR and WBC ），local wound condition （local pain disappearance time ，wound detumescence time ）， hospital stay ，laboratory indexes of important organs （AST，ALT，Scr，BUN，CKB，CK-MB），coagulation function index （t-PA， PAI-1，TAT，SFMC），wound inflammatory cell （macrophages，neutrophils，lymphocytes）count，serum levels of inflammatory cytokines（TNF-α，IL-1，IL-6，hs-CRP，NF-κB）and chemokine （MCP-1，CXCL-8）in 2 groups were significantly better than before treatment （P＜0.05）；most indexes of observation group were significantly better than those of control group （P＜0.05）. No severe ADR was found in 2 groups. CONCLUSIONS ：Jidesheng anti-venom tablet as auxiliary treatment can significantly reduce the local wound inflammation and systemic inflammatory response of snake bite patients ；the mechanism is probably related to reducing the levels of chemokine MCP- 1 and CXCL- 8 and inflammatory cytokines hs-CRP and NF-κB.
