Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy
10.11665/j.issn.1000-5048.20210401
- VernacularTitle:增氧型纳米递送系统用于光动力治疗的研究进展
- Author:
Chenkai SUN
1
;
Xin CHEN
;
Hao CHENG
;
Xiangze ZHANG
;
Xiaoyu YANG
;
Jianping ZHOU
;
Yang DING
Author Information
1. 中国药科大学药剂系，天然药物活性组分与药效国家重点实验室
- Publication Type:Journal Article
- Keywords:
nano-delivery system;
direct oxygen delivery;
in-situ oxygen production;
microbial oxygen supply;
synergistic photodynamic therapy;
advances
- From:
Journal of China Pharmaceutical University
2021;52(4):387-397
- CountryChina
- Language:Chinese
-
Abstract:
Photodynamic therapy, a new type of non-invasive treatment, is based on the principle that the photosensitizer excited by laser can transfer energy to oxygen, which generates cytotoxic singlet oxygen and thus induce tumor cell apoptosis or necrosis. As an oxygen-dependent therapy, the antitumor effect of photodynamic therapy is obviously limited by hypoxia environment of solid tumor tissue. Therefore, reversing and improving the hypoxia of tumor tissue can significantly enhance the efficacy of photodynamic therapy. This review focuses on the progress of tumor oxygenation strategy mediated by nano-delivery system, including direct oxygen delivery strategies, catalytic oxygen production strategies, responsive material in situ oxygen supply strategies and microorganism oxygen supply strategies, aiming to improve the antitumor effect of photodynamic therapy. It provides new ideas and new approaches for further study of oxygen-enchancing nano-delivery system for photodynamic therapy.
