Optimization of Ethanol Extraction Technology of Mongolian Medicine Naru- 3
- VernacularTitle:蒙药那如-3味的醇提工艺优化
- Author:
Jun LI
1
,
2
,
3
;
Yanli GU
3
;
Wen ZU
4
;
Yang LIU
3
;
Tuya BAI
1
,
2
,
3
;
Yuxia HU
1
,
2
,
3
;
Mengdi ZHANG
1
,
2
Author Information
1. Center for New Drug Safety Evaluation and Research，Inner Mongolia Medical University，Hohhot 010110，China
2. Research Center for Drug Screening，Inner Mongolia Medical University，Hohhot 010110，China
3. College of Pharmacy，Inner Mongolia Medical University，Hohhot 010110，China
4. Library of Inner Mongolia Medical University，Hohhot 010110，China
- Publication Type:Journal Article
- Keywords:
Naru-3;
Mongolian me dicine;
Ethanol extracti on technology;
Technology optimization;
Comprehensive score
- From:
China Pharmacy
2021;32(16):1988-1994
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To optim ize ethanol extraction technology of Mongolian medicine Naru- 3. METHODS ：The L 9（34） orthogonal design was used to optimize ethanol extraction technology of Mongolian medicine Naru- 3 with solid-liquid ratio ，ethanol volume fraction and extraction time as factors ，using comprehensive scores for the contents of benzoylaconitine ，benzoylneoaconitine， benzoylhypoaconitine，aconitine，neoaconitine，hypoaconitine，piperine and gallic acid as indexes. RESULTS ：The optimal ethanol extraction technology was that solid-liquid ratio of 1∶10（g/mL），ethanol volume fraction of 75％，extracting for 1.5 h. After 3 times of validation tests ，average contents of above 8 components in ethanol extract from Naru- 3 were 1.69，1.48，14.69，0.28， 0.05，0.08，26.01，17.33 mg/g（RSDs were 0-4.96％，n＝3），respectively. Average comprehensive score was 19.03（RSD＝1.42％， n＝3）. CONCLUSIONS ：The optimal ethanol extraction technology of Mongolian medicine Naru- 3 is stable and feasible.
