The Effects of Enamel Matrix Derivative and Calcium Sulfate Paste on the Healing of 1-Wall Intrabony Defects in Beagle Dogs.
10.5051/jkape.2000.30.3.539
- Author:
Seong Ho CHOI
1
;
Chang Sung KIM
;
Jong Jin SUH
;
Jeong Hye KIM
;
Hyun Young KIM
;
Kyoo Sung CHO
;
Chong Kwan KIM
Author Information
1. Department of Periodontology, College of Dentistry, Yonsei University Research Institute for Periodontal Regeneration, Korea.
- Publication Type:Original Article
- Keywords:
periodontal tissue regeneration;
enamel matrix derivative;
1-wall intrabony defect;
Caso4 sulfate patse
- MeSH:
Animals;
Calcium Sulfate*;
Calcium*;
Connective Tissue;
Debridement;
Dental Cementum;
Dental Enamel*;
Dogs*;
Epithelial Attachment;
Osteogenesis;
Regeneration
- From:The Journal of the Korean Academy of Periodontology
2000;30(3):539-552
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Recently, it was reported that enamel matrix derivative may be beneficial in periodontal regeneration procedures in expectation of promoting new bone and cementum formation. The aim of present study was to evaluate the effect of enamel matrix derivative(Emdogain?)and Caso4 sulfate paste in 1-wall intrabony defects in beagle dogs. Surgically created 1-wall intrabony defects were randomly assigned to receive root debridement alone or Emdogain(R) or Emdogain(R) and Caso4. Clinical defect size was 4 X 4mm. The control group was treated with root debridement alone,and Experimental group I was treated with enamel matrix derivative application, and Experimental group II was treated with enamel matrix derivative and Caso4 sulfate paste application,. The healing processes were histologically and histometrically observed after 8 weeks and the results were as follows : 1. The length of junctional epithelium was 0.41+/-0.01mm in the control group, 0.42+/-0.08mm in the experimental group I and 0.50+/-0.13mm in the experimental group II. 2. The connective tissue adhesion was 0.28+/-0.02 mm in the control group, 0.13+/-0.08mm in the experimental group I and 0.19+/-0.02 mm in the experimental group II. 3. The new cementum formation was 3.80+/-0.06 mm in the control group, 4.12+/-0.43mm in the experimental group I and 4.34+/-0.71mm in the experimental group II. 4. The new bone formation was 1.43+/-0.03mm in the control group, 1.53+/-0.47 mm in the experimental group I and 2.25+/-1.35mm in the experimental group II. Although there was limitation to present study, the use of enamel matrix derivative in the treatment of periodontal 1-wall intrabony defect enhanced new cementum and bone formation. Caso4 sulfate paste will be the candidate for carriers to deliver enamel matrix derivative, and so enhance the regenerative potency of enamel matrix derivative.
