Role of mitochondrial injury in the development and progression of nonalcoholic fatty liver disease
DOI:10.3969/j.issn.1001-5256.2021.07.005
- VernacularTitle:线粒体损伤在非酒精性脂肪性肝病发生发展中的作用
- Author:
Weichun XIAO
1
;
Wei AN
Author Information
1. Beijing Key Laboratory of Liver Protection and Regulation of Regeneration, Department of Cell Biology, Capital Medical University, Beijing 100069, China
- Publication Type:Research Article
- Keywords:
Mitochondria;
Non-alcoholic Fatty Liver Disease;
Lipid Metabolism
- From:
Journal of Clinical Hepatology
2021;37(7):1515-1521.
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are an important organelle and can regulate lipid metabolism, oxidative phosphorylation, and ATP synthesis. Disorder of mitochondria biosynthesis, loss of mitochondrial homeostasis, and even mitochondrial structural damage will lead to lipid metabolism disorders and oxidative stress. Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid accumulation in hepatocytes. NAFLD is a progressive disease manifesting as the process from hepatocyte steatosis to steatohepatitis, liver fibrosis, and liver cirrhosis. It is currently believed that mitochondria play an important role in the onset of NAFLD, and thus NAFLD is also referred to as “mitochondrial disease”. This article reviews the association of mitochondrial injury, such as lipid metabolism disorders, change in reactive oxygen species, and loss of mitochondrial homeostasis, with the development and progression of NAFLD.
