Biological characteristics of tumor infiltrating regulatory T cells and the application of regulatory T cells in tumor immunotherapy

VernacularTitle:肿瘤浸润调节性T细胞生物学特性及调节性T细胞在肿瘤免疫治疗中的应用
Author: Hongbo NI ; Hui FENG
From: Cancer Research and Clinic 2021;33(5):397-400
CountryChina
Language:Chinese
Abstract: Regulatory T cells (Treg cells) have a critical role in the maintenance of immune homeostasis. However, tumor infiltrating Treg (TITR) contributes to weaken anti-tumor specific immune response through enhancing immunosuppressive effect in tumor microenvironment (TME), leading to tumor escape from immune surveillance. Recently, Treg cells-based immunotherapy has achieved good anti-tumor effects with the appearance of immune checkpoint inhibitors, chemokines and their receptors antagonists, specific Treg cells selective target genes knockout and novel drugs. This paper reviews the biological characteristics of TITR and discusses the prospect and application of Treg cells-based immunotherapy.