Progress of cell death induced by Neddylation modification pathway inhibitor MLN4924
10.3760/cma.j.cn115355-20191215-00575
- VernacularTitle:Neddylation修饰通路抑制剂MLN4924诱导细胞死亡的研究进展
- Author:
Jingrong XIAN
;
Shiwen WANG
;
Yue LIU
;
Yanmei ZHANG
;
Hu ZHAO
- From:
Cancer Research and Clinic
2021;33(5):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Protein ubiquitin-like modification of Neddylation is an important post-translational modification mode of protein to widely regulate cell cycle, growth, development and other biological processes. Recent studies have found that MLN4924, small molecule inhibitor of Neddylation modification, has a significant anti-tumor effect, which can inhibit the tumor growth by inducing cell cycle arrest, senescence and apoptosis, and inhibiting tumor angiogenesis. This paper reviews the related mechanism research of cell programmed death induced by Neddylation modification pathway inhibitor MLN4924.
