Progress of long non-coding RNA DANCR in thyroid cancer
10.3760/cma.j.cn115355-20200624-00345
- 白话标题:长链非编码RNA DANCR在甲状腺癌中的研究进展
- 作者:
Lili ZHONG
;
Yuanjuan CHENG
;
Jingru MA
;
Yinlong ZHAO
- 来源:
Cancer Research and Clinic
2021;33(4):314-317
- 国家China
- 语言:Chinese
-
摘要:
Thyroid cancer is the most common head and neck malignant tumor, and its incidence is increasing year by year. Therefore, it is of great significance to explore the mechanism of the occurrence and development of thyroid cancer, and develop the diagnostic markers and therapeutic targets of thyroid cancer, so as to improve the curative effect of thyroid cancer and prolong the survival time of patients. The previous study has found that long non-coding RNA (lncRNA) DANCR has abnormal high expression in thyroid cancer, which could promote the expression of leucine-rich repeat kinase 2 (LRRK2) by affecting miRNA-185-5p and transcription factor SMARCB1, and indirectly participate in autophagy and regulate the development of thyroid cancer. LncRNA DANCR is expected to become a new target for diagnosis and treatment of thyroid cancer. This paper introduces the possible regulatory mechanism of lncRNA DANCR in thyroid cancer, and provides new ideas for the basic research and clinical diagnosis and treatment of thyroid cancer.
