Progress of cancer-associated fibroblasts in breast cancer
10.3760/cma.j.cn115355-20200218-00060
- VernacularTitle:肿瘤相关成纤维细胞在乳腺癌中的研究进展
- Author:
Kaixin BI
;
Yafen ZHANG
;
Yuchen HAO
;
Xiaoqing LIU
- From:
Cancer Research and Clinic
2021;33(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Tumor tissue is a complex of tumor cells, stromal cells, and extracellular matrix, and they constitute a disordered and aggressive microenvironment, which plays an indispensable role in the occurrence and development of tumors. In breast cancer, cancer-associated fibroblasts (CAF) not only promote the occurrence, proliferation, invasion, metastasis, and drug resistance of tumor, but also participate in events including angiogenesis, lymph angiogenesis, extracellular matrix remodeling, and reconstruction of the microenvironment, which are known to induce cancer. Therefore, a new strategy for tumor therapy is provided by targeting CAF. This article reviews the research progress of CAF in breast cancer.
