Progress of tumor-associated macrophages in glioma
10.3760/cma.j.cn115355-20200522-00270
- VernacularTitle:神经胶质瘤中肿瘤相关巨噬细胞研究进展
- Author:
Yu ZHANG
;
Hubin DUAN
- From:
Cancer Research and Clinic
2021;33(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophage (TAM) is a group of heterogeneous cells and a major component of inflammatory cells in the tumor microenvironment. Parts of these cells in gliomas are derived from central nervous system microglia and circulating monocytes, and have been implicated in angiogenesis, immunosuppression, tumor progression and invasion of gliomas. This article reviews the potential mechanisms of TAM promoting glioma development through various pathways to provide new possibilities for targeted therapy of gliomas.
