Important prospects of EV DNA in tumor diagnosis
10.3760/cma.j.cn114452-20200702-00591
- VernacularTitle:细胞外囊泡DNA在肿瘤诊断中具有重要应用前景
- Author:
Yanjun DIAO
;
Weixiao FAN
;
Liu YANG
;
Jiayun LIU
;
Xiaoke HAO
- From:
Chinese Journal of Laboratory Medicine
2021;44(5):367-371
- CountryChina
- Language:Chinese
-
Abstract:
As a new type of intercellular signaling rector, extracellular vesicles (EV) are involved in almost the whole process of tumorigenesis, progression, metastasis, and drug resistance. Therefore, EV have become the ideal biomarker candidates and research hotspots for cancer diagnosis and treatment. However, EV tumor biomarker research mainly focused on RNA and protein, and a small part of the research focused on lipids at the early stage. EV DNA has received little attention and its diagnostic value has gradually been recognized in recent years. Study on the biological characteristics and function of EV DNA may highlight its potential in tumor diagnosis.
