Progress of circulating RNA in liquid biopsy of cervical cancer

VernacularTitle:血液循环RNA在宫颈癌液体活检中的研究进展
Author: Haixia LUO ; Wei WANG ; Min HAO
From: Chinese Journal of Laboratory Medicine 2021;44(4):352-357
CountryChina
Language:Chinese
Abstract: Cervical cancer poses a major threat to public health worldwide, early diagnosis of cervical cancer can improve the survival rate of patients. The detection rate of the existing cervical cancer screening methods is not very stable, and there is no reliable non-invasive index to predict the recurrence, metastasis and prognosis of cervical cancer. We searched literaruture for cervical cancer-related diagnostic and prognostic indicators and included 20 related literature, confirming that liquid biopsy is expected to replace and supplement the existing methods of screening and testing. Circulating nucleotides are an important part of liquid bioassays, including circulating cell-free DNA (cfDNA) and circulating cell-free RNA (cfRNA), among which cfRNA is a potentially rich source of tumor biomarkers, especially in the early diagnosis of cervical cancer. It has unique specificity and great potential value in the early diagnosis.