Application of extracellular vesicles in tumor diagnosis

VernacularTitle:细胞外囊泡在肿瘤诊断中的应用
Author: Yanjun DIAO ; Weixiao FAN ; Xiaoke HAO
From: Chinese Journal of Laboratory Medicine 2021;44(3):255-259
CountryChina
Language:Chinese
Abstract: Extracellular vesicles (EV) are widely distributed, rich in content, and fully participate in the regulation of important cellular physiological activities. As a new technology for tumor diagnosis, the natural advantages of EV include protecting its contents, being easy to obtain from various biofluids, having the potential to be truly non-invasive and high tissue fidelity. In order to transfer EV for clinical use, many isolation technologies such as microfluidics, immunochips, nano-flow cytometry and acoustic capture have been continuously developed. At present, several EV tumor diagnostic products have been applied in the clinical setting. However, due to the great differences in detection methods and platforms, there are still some technical difficulties in its clinical applications. With the accumulation of clinical evidence and the continuous improvement of clinical diagnostic methods, the liquid biopsy based on EV can finally be applied in the clinic.